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Editorial Board
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CO2
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Cytokine research in Belgium
At first glance an entire issue of a journal devoted to “Cytokine research in Belgium” is a somewhat bizarre way of assembling a series of reviews. Has a survey been done of cytokine paper output per ...
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Walter Fiers
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255-256
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NOD-like receptors and the innate immune system: Coping with danger, damage and death
13 October 2011
Abstract: Members of the family of NOD-like receptors (NLRs) play essential roles in innate immunity by detecting intracellular ‘pathogen-associated molecular patterns’ (PAMPs) and ‘danger-associated ...
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Kristof Kersse,
Mathieu J.M. Bertrand,
Mohamed Lamkanfi,
Peter Vandenabeele
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257-276
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Regulation of TNF-induced NF-κB activation by different cytoplasmic ubiquitination events
28 November 2011
Abstract: TNF is a multifunctional cytokine that plays a key role in innate immunity by inducing the expression of a variety of genes that are involved in an inflammatory response. TNF-induced NF-κB a...
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Kelly Verhelst,
Isabelle Carpentier,
Rudi Beyaert
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277-286
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Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo
28 November 2011
Abstract: Signaling by the many ligands of the TGFβ family strongly converges towards only five receptor-activated, intracellular Smad proteins, which fall into two classes i.e. Smad2/3 and Smad1/5/8,...
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Andrea Conidi,
Silvia Cazzola,
Karen Beets,
Kathleen Coddens,
Clara Collart,
Frederique Cornelis,
Luk Cox,
Debruyn Joke,
Mariya P. Dobreva,
Ruben Dries,
Camila Esguerra,
Annick Francis,
Abdelilah Ibrahimi,
Roel Kroes,
Flore Lesage,
Elke Maas,
Ivan Moya,
Paulo N.G. Pereira,
Elke Stappers,
Agata Stryjewska,
Veronique van den Berghe,
Liesbeth Vermeire,
Griet Verstappen,
Eve Seuntjens,
Lieve Umans,
An Zwijsen,
Danny Huylebroeck
et al.
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287-300
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Biology and signal transduction pathways of the Lymphotoxin-αβ/LTβR system
Abstract: This review focuses on the biological functions and signalling pathways activated by Lymphotoxin α (LTα)/Lymphotoxin β (LTβ) and their receptor LTβR. Genetic mouse models shed light on cruci...
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Caroline Remouchamps,
Layla Boutaffala,
Corinne Ganeff,
Emmanuel Dejardin
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301-310
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Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1
03 October 2011
Abstract: The TNF signaling pathway is a valuable target in the therapy of autoimmune diseases, and anti-TNF drugs are successfully used to treat diseases such as rheumatoid arthritis, Crohn's disease...
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Filip Van Hauwermeiren,
Roosmarijn E. Vandenbroucke,
Claude Libert
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311-319
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MAPPIT: A protein interaction toolbox built on insights in cytokine receptor signaling
28 November 2011
Abstract: MAPPIT (mammalian protein–protein interaction trap) is a two-hybrid interaction mapping technique based on functional complementation of a type I cytokine receptor signaling pathway. Over th...
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Sam Lievens,
Frank Peelman,
Karolien De Bosscher,
Irma Lemmens,
Jan Tavernier
et al.
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321-329
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Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism
28 November 2011
Abstract: Chemerin was isolated as the natural ligand of the G protein-coupled receptor ChemR23. Chemerin acts as a chemotactic factor for leukocyte populations expressing ChemR23, particularly immatu...
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Benjamin Bondue,
Valérie Wittamer,
Marc Parmentier
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331-338
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Collagen-induced arthritis and related animal models: How much of their pathogenesis is auto-immune, how much is auto-inflammatory?
28 November 2011
Abstract: In this review, we discuss our studies on the pathogenesis of collagen-induced arthritis (CIA) and related mouse models for rheumatoid arthritis. Of note, these models invariably rely on the...
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Alfons Billiau,
Patrick Matthys
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339-344
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The expression and role of CXC chemokines in colorectal cancer
17 October 2011
Abstract: Cancer is a life-threatening disease world-wide and colorectal cancer is the second common cause of cancer mortality. The interaction between tumor cells and stromal cells plays a crucial ro...
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Hannelien Verbeke,
Sofie Struyf,
Geneviève Laureys,
Jo Van Damme
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345-358
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Probing cytokines, chemokines and matrix metalloproteinases towards better immunotherapies of multiple sclerosis
28 November 2011
Abstract: Multiple sclerosis (MS) is an autoimmune disease with a spectrum of clinical evolutions. We here summarize recent insights into the neuroinflammatory processes of demyelination, vascular cuf...
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Ghislain Opdenakker,
Jo Van Damme
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359-365
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