Cytokine & Growth Factor Reviews
Volume 22, Issue 5 , Pages 287-300 , October 2011

Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

  • Andrea Conidi

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Shared first authors.
    • Tel.: +32 16 373135; fax: +32 16 372581.
    • ,
  • Silvia Cazzola

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Shared first authors.
    • Tel.: +32 16 373137; fax: +32 16 372581.
    • ,
  • Karen Beets

      Affiliations

    • Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 10 753025; fax: +32 10 753000.
    • ,
  • Kathleen Coddens

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 373137; fax: +32 16 372581.
    • ,
  • Clara Collart

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Present address: Systems Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. Tel.: +44 20 8816 2272; fax: +44 20 8906 4477.
    • ,
  • Frederique Cornelis

      Affiliations

    • Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Present address: Division of Rheumatology, University of Leuven, Campus Gasthuisberg, Building Ond&Nav1, Herestraat 49, B-3000 Leuven, Belgium. Tel.: +32 16 346151; fax: +32 16 346200.
    • ,
  • Luk Cox

      Affiliations

    • Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Present address: Laboratory of Molecular Pathogenesis of Leukemia of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium. Tel.: +32 16 330119; fax: +32 16 330084.
    • ,
  • Debruyn Joke

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 10 753025; fax: +32 10 753000.
    • ,
  • Mariya P. Dobreva

      Affiliations

    • Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 330724; fax: +32 16 372581.
    • ,
  • Ruben Dries

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 373137; fax: +32 16 372581.
    • ,
  • Camila Esguerra

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Present address: Laboratory of Pharmaceutical Biology, University of Leuven, Campus Gasthuisberg, Building Ond&Nav2 Herestraat 49, B-3000 Leuven, Belgium. Tel.: +32 16 323439; fax: +32 16 323460.
    • ,
  • Annick Francis

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 373137; fax: +32 16 372581.
    • ,
  • Abdelilah Ibrahimi

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 495 221103; fax: +32 10 753000.
    • ,
  • Roel Kroes

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 373135; fax: +32 16 372581.
    • ,
  • Flore Lesage

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 373135; fax: +32 16 372581.
    • ,
  • Elke Maas

      Affiliations

    • Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 373169; fax: +32 16 372581.
    • ,
  • Ivan Moya

      Affiliations

    • Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 330724; fax: +32 16 372581.
    • ,
  • Paulo N.G. Pereira

      Affiliations

    • Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 330006; fax: +32 16 372581.
    • ,
  • Elke Stappers

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 373135; fax: +32 16 372581.
    • ,
  • Agata Stryjewska

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 373137; fax: +32 16 372581.
    • ,
  • Veronique van den Berghe

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 373135; fax: +32 16 372581.
    • ,
  • Liesbeth Vermeire

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Present address: InfraMouse, Animal facility, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. Tel.: +32 16 330757; fax: +32 16 372581.
    • ,
  • Griet Verstappen

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 373135; fax: +32 16 372581.
    • ,
  • Eve Seuntjens

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 373135; fax: +32 16 372581.
    • ,
  • Lieve Umans

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 373137; fax: +32 16 372581.
    • ,
  • An Zwijsen

      Affiliations

    • Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
    • Tel.: +32 16 330006; fax: +32 16 372581.
    • ,
  • Danny Huylebroeck

      Affiliations

    • Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
    • Corresponding Author InformationCorresponding author at: Laboratory of Molecular Biology (Celgen), c/o Stem Cell Institute, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 (room 05.313), Herestraat 49, B-3000 Leuven, Belgium. Tel.: +32 16 373139; fax: +32 16 372581.

References 

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PII: S1359-6101(11)00059-1

doi: 10.1016/j.cytogfr.2011.11.006

Cytokine & Growth Factor Reviews
Volume 22, Issue 5 , Pages 287-300 , October 2011

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