Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

Conidi, Andrea; Cazzola, Silvia; Beets, Karen; Coddens, Kathleen; Collart, Clara; Cornelis, Frederique; Cox, Luk; Joke, Debruyn; Dobreva, Mariya P.; Dries, Ruben; Esguerra, Camila; Francis, Annick; Ibrahimi, Abdelilah; Kroes, Roel; Lesage, Flore; Maas, Elke; Moya, Ivan; Pereira, Paulo N.G.; Stappers, Elke; Stryjewska, Agata; van den Berghe, Veronique; Vermeire, Liesbeth; Verstappen, Griet; Seuntjens, Eve; Umans, Lieve; Zwijsen, An; Huylebroeck, Danny

doi:10.1016/j.cytogfr.2011.11.006

« Previous Next »Cytokine & Growth Factor Reviews
Volume 22, Issue 5 , Pages 287-300, October 2011

Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

Andrea Conidi
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Shared first authors.
- Tel.: +32 16 373135; fax: +32 16 372581.
Silvia Cazzola
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Shared first authors.
- Tel.: +32 16 373137; fax: +32 16 372581.
Karen Beets
- Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 10 753025; fax: +32 10 753000.
Kathleen Coddens
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 373137; fax: +32 16 372581.
Clara Collart
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Present address: Systems Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. Tel.: +44 20 8816 2272; fax: +44 20 8906 4477.
Frederique Cornelis
- Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Present address: Division of Rheumatology, University of Leuven, Campus Gasthuisberg, Building Ond&Nav1, Herestraat 49, B-3000 Leuven, Belgium. Tel.: +32 16 346151; fax: +32 16 346200.
Luk Cox
- Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Present address: Laboratory of Molecular Pathogenesis of Leukemia of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium. Tel.: +32 16 330119; fax: +32 16 330084.
Debruyn Joke
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 10 753025; fax: +32 10 753000.
Mariya P. Dobreva
- Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 330724; fax: +32 16 372581.
Ruben Dries
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 373137; fax: +32 16 372581.
Camila Esguerra
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Present address: Laboratory of Pharmaceutical Biology, University of Leuven, Campus Gasthuisberg, Building Ond&Nav2 Herestraat 49, B-3000 Leuven, Belgium. Tel.: +32 16 323439; fax: +32 16 323460.
Annick Francis
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 373137; fax: +32 16 372581.
Abdelilah Ibrahimi
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 495 221103; fax: +32 10 753000.
Roel Kroes
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 373135; fax: +32 16 372581.
Flore Lesage
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 373135; fax: +32 16 372581.
Elke Maas
- Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 373169; fax: +32 16 372581.
Ivan Moya
- Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 330724; fax: +32 16 372581.
Paulo N.G. Pereira
- Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 330006; fax: +32 16 372581.
Elke Stappers
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 373135; fax: +32 16 372581.
Agata Stryjewska
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 373137; fax: +32 16 372581.
Veronique van den Berghe
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 373135; fax: +32 16 372581.
Liesbeth Vermeire
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Present address: InfraMouse, Animal facility, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. Tel.: +32 16 330757; fax: +32 16 372581.
Griet Verstappen
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 373135; fax: +32 16 372581.
Eve Seuntjens
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 373135; fax: +32 16 372581.
Lieve Umans
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 373137; fax: +32 16 372581.
An Zwijsen
- Laboratory of Developmental Signaling of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), Campus Gasthuisberg, Building Ond&Nav4 level 06, Herestraat 49, B-3000 Leuven, Belgium
- Tel.: +32 16 330006; fax: +32 16 372581.
Danny Huylebroeck
- Laboratory of Molecular Biology (Celgen) of the Center for Human Genetics, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Department of Molecular and Developmental Genetics (VIB11), University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 level 05, Herestraat 49, B-3000 Leuven, Belgium
- Corresponding author at: Laboratory of Molecular Biology (Celgen), c/o Stem Cell Institute, University of Leuven, Campus Gasthuisberg, Building Ond&Nav4 (room 05.313), Herestraat 49, B-3000 Leuven, Belgium. Tel.: +32 16 373139; fax: +32 16 372581.