Cytokine & Growth Factor Reviews
Volume 22, Issue 5 , Pages 277-286, October 2011

Regulation of TNF-induced NF-κB activation by different cytoplasmic ubiquitination events

  • Kelly Verhelst

      Affiliations

    • Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium
    • Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
    • ,
  • Isabelle Carpentier

      Affiliations

    • Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium
    • Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
    • ,
  • Rudi Beyaert

      Affiliations

    • Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium
    • Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
    • Corresponding Author InformationCorresponding author at: Technologiepark 927, 9052 Ghent, Belgium. Tel.: +32 9 331 37 70; fax: +32 9 331 36 09.

published online 28 November 2011.

Abstract 

TNF is a multifunctional cytokine that plays a key role in innate immunity by inducing the expression of a variety of genes that are involved in an inflammatory response. TNF-induced NF-κB activation is one of the best studied signaling pathways in mammalian cells and has recently led to a revival of research in the biology of ubiquitin. Many NF-κB signaling proteins are modified by specific ubiquitin ligases with different types of ubiquitin chains that are recognized by other proteins and which determine the outcome of ubiquitination. In addition, specific de-ubiquitinases make the whole process reversible. This review summarizes recent findings that have shaped our current understanding on the role of cytoplasmic ubiquitination events in the regulation of TNF-induced NF-κB signaling.

Keywords: TNF, NF-κB, Ubiquitin, A20, Immunity

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PII: S1359-6101(11)00055-4

doi:10.1016/j.cytogfr.2011.11.002

Cytokine & Growth Factor Reviews
Volume 22, Issue 5 , Pages 277-286, October 2011

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