Cytokine & Growth Factor Reviews
Volume 21, Issue 4 , Pages 275-286, August 2010

Crosstalk between TNF and glucocorticoid receptor signaling pathways

  • Tom Van Bogaert

      Affiliations

    • Department of Biomedical Molecular Biology, Ghent University, Belgium
    • Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    • ,
  • Karolien De Bosscher

      Affiliations

    • Laboratory for Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Physiology, Ghent University, Belgium
    • ,
  • Claude Libert

      Affiliations

    • Department of Biomedical Molecular Biology, Ghent University, Belgium
    • Department for Molecular Biomedical Research, VIB, Ghent, Belgium
    • Corresponding Author InformationCorresponding author at: DMBR, Technologypark, 927, 9052 Ghent, Belgium. Tel.: +32 9 3313700.

published online 26 April 2010.

Abstract 

TNF is a Janus-faced protein. It possesses impressive anti-tumor activities, but it is also one of the strongest known pro-inflammatory cytokines, which hampers its use as a systemic anti-cancer agent. TNF has been shown to play a detrimental role in inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Glucocorticoids are strongly anti-inflammatory and exert their therapeutic effects through binding to their receptor, the glucocorticoid receptor. Therefore, glucocorticoids have been used for over half a century for the treatment of inflammatory diseases. However, many patients are or become resistant to the therapeutic effects of glucocorticoids. Inflammatory cytokines have been suggested to play an important role in this steroid insensitivity or glucocorticoid resistance. This review aims to highlight the mechanisms of mutual inhibition between TNF and GR signaling pathways.

Keywords: TNF, Nuclear receptors, Crosstalk, Steroids

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PII: S1359-6101(10)00032-8

doi:10.1016/j.cytogfr.2010.04.003

Cytokine & Growth Factor Reviews
Volume 21, Issue 4 , Pages 275-286, August 2010

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