Cytokine & Growth Factor Reviews
Volume 21, Issue 4 , Pages 253-262, August 2010

The evolution of mammalian chemokine genes

  • Hisayuki Nomiyama

      Affiliations

    • Department of Molecular Enzymology, Faculty of Life Sciences, Kumamoto University, Honjo, Kumamoto 860-8556, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 96 373 5065; fax: +81 96 373 5066.
    • ,
  • Naoki Osada

      Affiliations

    • Division of Evolutionary Genetics, Department of Population Genetics, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan
    • ,
  • Osamu Yoshie

      Affiliations

    • Department of Microbiology, Kinki University School of Medicine, Osaka-Sayama, Osaka 589-8511, Japan

published online 03 May 2010.

Abstract 

Chemokines play an important role in orchestrating cell recruitment and localization in both physiological and pathological conditions. More than 44 ligands have been identified in the human genome. A significantly different set of chemokines, however, is found in the mouse genome, suggesting a rapid evolution of the chemokine system in mammalian genomes. Thus, there are lineage and even individual-specific differences in chemokine genes in mammals. Differences in the expression and function between even recently duplicated genes are also evident. In this review, we discuss how evolutionary events such as gene duplication and gene conversion have shaped the diverse arrays of chemokines in mammalian genomes.

Keywords: Cluster chemokines, Gene family, Gene duplication, Gene conversion

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PII: S1359-6101(10)00029-8

doi:10.1016/j.cytogfr.2010.03.004

Cytokine & Growth Factor Reviews
Volume 21, Issue 4 , Pages 253-262, August 2010

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