Cytokine & Growth Factor Reviews
Volume 21, Issue 1 , Pages 27-39, February 2010

The chemokine system in cancer biology and therapy

  • Alberto Mantovani

      Affiliations

    • Department of Translational Medicine, University of Milan, I-20089 Rozzano, Milan, Italy
    • IRCCS Istituto Clinico Humanitas, I-20089 Rozzano, Milan, Italy
    • Corresponding Author InformationCorresponding author at: IRCCS Istituto Clinico Humanitas, Via Manzoni 56, I-20089 Rozzano, Italy, Tel.: +39 02 8224 2444; fax: +39 02 8224 5101.
    • ,
  • Benedetta Savino

      Affiliations

    • Department of Translational Medicine, University of Milan, I-20089 Rozzano, Milan, Italy
    • IRCCS Istituto Clinico Humanitas, I-20089 Rozzano, Milan, Italy
    • ,
  • Massimo Locati

      Affiliations

    • Department of Translational Medicine, University of Milan, I-20089 Rozzano, Milan, Italy
    • IRCCS Istituto Clinico Humanitas, I-20089 Rozzano, Milan, Italy
    • ,
  • Luca Zammataro

      Affiliations

    • IRCCS Istituto Clinico Humanitas, I-20089 Rozzano, Milan, Italy
    • ,
  • Paola Allavena

      Affiliations

    • IRCCS Istituto Clinico Humanitas, I-20089 Rozzano, Milan, Italy
    • ,
  • Raffaella Bonecchi

      Affiliations

    • Department of Translational Medicine, University of Milan, I-20089 Rozzano, Milan, Italy
    • IRCCS Istituto Clinico Humanitas, I-20089 Rozzano, Milan, Italy

published online 09 December 2009.

Abstract 

Chemokines are a key component of cancer-related inflammation. Chemokines and chemokine receptors are downstream of genetic events that cause neoplastic transformation and are components of chronic inflammatory conditions, which predispose to cancer. Components of the chemokine system affect in a cell autonomous or non-autonomous way multiple pathways of tumor progression, including: leukocyte recruitment and function; cellular senescence; tumor cell proliferation and survival; invasion and metastasis. Available information in preclinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.

Keywords: Chemokine, Cancer, Chemokine Receptor, Inflammation

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PII: S1359-6101(09)00114-2

doi:10.1016/j.cytogfr.2009.11.007

Cytokine & Growth Factor Reviews
Volume 21, Issue 1 , Pages 27-39, February 2010

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