Cytokine & Growth Factor Reviews
Volume 21, Issue 1 , Pages 61-65, February 2010

The resolution of inflammation and cancer

Inflammation Biology Group, Centre d’Immunologie Marseile-Luminy, Parc Scientifique de Luminy Case 906, 13288 Marseille, France1

published online 21 December 2009.

Abstract 

Inflammation has long been thought to contribute to the development of cancer; however there is also clear evidence that the immune system can recognize and eliminate cancer cells. Current research suggests that cancer-associated inflammation has a dual role in tumor progression; inflammatory mediators promote the malignant activity of cancer cells by acting as growth factors and also stimulate angiogenesis, however, cancer-associated inflammation is also linked with immune-suppression that allows cancer cells to evade detection by the immune system. In this review we will discuss the dual role of inflammation in cancer and how endogenous anti-inflammatory mechanisms may equally be important in carcinogenesis.

Keywords: Inflammation, Cancer, Macrophage, Resolution, Anti-inflammatory mechanisms

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S1359-6101(09)00113-0

doi:10.1016/j.cytogfr.2009.11.006

Cytokine & Growth Factor Reviews
Volume 21, Issue 1 , Pages 61-65, February 2010