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Cytokine & Growth Factor Reviews
Volume 21, Issue 1
, Pages 3-10
, February 2010
Lymphocytes in cancer development: Polarization towards pro-tumor immunity
References
- . Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis. 2009;30:1073–1081
- . Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res. 2007;67:9518–9527
- . Immune cells and inflammatory mediators as regulators of tumor angiogenesis. In: Figg WD, Folkman J editor. Angiogenesis: an integrative approach from science to medicine. New York: Springer; 2008;p. 225–238
- . Cancer-related inflammation. Nature. 2008;454:436–444
- . Inflammation and cancer. Nature. 2002;420:860–867
- . Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell. 2005;7:211–217
- . Trophic macrophages in development and disease. Nat Rev Immunol. 2009;9:259–270
- . Microenvironmental regulation of metastasis. Nat Rev Cancer. 2009;9:239–252
- . Distinct role of macrophages in different tumor microenvironments. Cancer Res. 2006;66:605–612
- . Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol. 2009;9:91–105
- . Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med. 1994;180:1715–1728
- Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol. 2009;182:3469–3481
- . Generation and regulation of CD8(+) regulatory T cells. Cell Mol Immunol. 2008;5:401–406
- . Control points in NKT-cell development. Nat Rev Immunol. 2007;7:505–518
- . T cells: functional plasticity and heterogeneity. Nat Rev Immunol. 2002;2:336–345
- . The three Es of cancer immunoediting. Annu Rev Immunol. 2004;22:329–360
- . Paradoxical roles of the immune system during cancer development. Nat Rev Cancer. 2006;6:24–37
- Regulation of cutaneous malignancy by gammadelta T cells. Science. 2001;294:605–609
- . Immune enhancement of skin carcinogenesis by CD4+ T cells. J Exp Med. 2003;197:1017–1028
- Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992-2003. Ann Intern Med. 2008;148:728–736
- . AIDS-related malignancies. Nat Rev Cancer. 2002;2:373–382
- De Novo neoplasia after liver transplantation: an analysis of risk factors and influence on survival. Liver Transpl. 2005;11:89–97
- . De novo malignancies after liver transplantation: a major cause of late death. Liver Transpl. 2001;7:S109–S118
- . Cancer and autoimmunity: autoimmune and rheumatic features in patients with malignancies. Ann Rheum Dis. 2001;60:433–441
- . A common repertoire of autoantibodies is shared by cancer and autoimmune disease patients: Inflammation in their induction and impact on tumor growth. Cancer Lett. 2009;281:8–23
- . Functions of natural killer cells. Nat Immunol. 2008;9:503–510
- . Control of regulatory T cell lineage commitment and maintenance. Immunity. 2009;30:616–625
- . Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?. Immunity. 2009;30:626–635
- . Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol. 2006;6:295–307
- Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma. Cancer Res. 2005;65:5020–5026
- . In vivo sites and cellular mechanisms of T reg cell-mediated suppression. J Exp Med. 2006;203:489–492
- Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity. 2009;30:458–469
- . How regulatory T cells work. Nat Rev Immunol. 2008;8:523–532
- . The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol. 2008;9:239–244
- . A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment. Clin Cancer Res. 2007;13:4345–4354
- . Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J Exp Med. 2005;201:779–791
- . Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity. 2007;27:635–646
- . Immunosuppressor T cells in tumor bearing host. Immunol Commun. 1975;4:201–217
- . T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor. J Exp Med. 1980;151:69–80
- . Immunologically mediated regression of a murine lymphoma after treatment with anti-L3T4 antibody. A consequence of removing L3T4+ suppressor T cells from a host generating predominantly Lyt-2+ T cell-mediated immunity. J Exp Med. 1988;168:2193–2206
- Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004;10:942–949
- . The impact of regulatory T cells on carcinogen-induced sarcogenesis. Br J Cancer. 2007;96:1849–1854
- Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol. 2007;25:2586–2593
- . Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin Cancer Res. 2006;12:5423–5434
- Human leukocyte antigen class I. MHC class I chain-related molecule A, and CD8+/regulatory T-cell ratio: which variable determines survival of cervical cancer patients?. Clin Cancer Res. 2008;14:2028–2035
- . Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients. Cancer. 2006;107:2866–2872
- . Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. J Clin Oncol. 2006;24:5373–5380
- FOXP3 expression and overall survival in breast cancer. J Clin Oncol. 2009;27:1746–1752
- . Regulating the immune response to tumours. Adv Drug Deliv Rev. 2006;58:948–961
- . Regulatory T cells in ovarian cancer: biology and therapeutic potential. Am J Reprod Immunol. 2005;54:369–377
- Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest. 2005;115:3623–3633
- A Phase II Trial of Denileukin Diftitox in Patients With Previously Treated Advanced Non-Small Cell Lung Cancer. Am J Clin Oncol. 2009;
- . Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res. 1999;59:3128–3133
- . Anti-cytotoxic T-lymphocyte antigen-4 antibody: the first in an emerging class of immunomodulatory antibodies for cancer treatment. J Clin Oncol. 2008;26:5275–5283
- . Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity. 2006;24:677–688
- . TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol. 2008;8:337–348
- . The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity. 2008;28:454–467
- . Induction and effector functions of T(H)17 cells. Nature. 2008;453:1051–1057
- . Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer. Proc Natl Acad Sci USA. 2008;105:15505–15510
- Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clin Cancer Res. 2008;14:3254–3261
- The prevalence of Th17 cells in patients with gastric cancer. Biochem Biophys Res Commun. 2008;374:533–537
- Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol. 2009;50:980–989
- IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol. 2005;175:6177–6189
- Interleukin-17 promotes angiogenesis and tumor growth. Blood. 2003;101:2620–2627
- Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17. Cancer Res. 2008;68:3915–3923
- . IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation. Cancer Res. 2009;69:2010–2017
- . IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med. 2009;206:1457–1464
- . Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol. 2007;7:41–51
- . Role of Stat3 in suppressing anti-tumor immunity. Curr Opin Immunol. 2008;20:228–233
- Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci USA. 2006;103:8137–8142
- . Endogenous IL-17 contributes to reduced tumor growth and metastasis. Blood. 2009;114:357–359
- Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood. 2008;112:362–373
- . Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol. 2008;26:57–79
- Adaptive immunity maintains occult cancer in an equilibrium state. Nature. 2007;450:903–907
- . Characterizing the protective component of the alphabeta T cell response to transplantable squamous cell carcinoma. J Invest Dermatol. 2004;122:699–706
- . CD4+ T Cell-mediated antigen-specific immunotherapy in a mouse model of cervical cancer. Cancer Res. 2005;65:2018–2025
- . CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell. 2009;16:91–102
- . Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression. Eur J Cancer. 2004;40:1660–1667
- . Polarized immune responses differentially regulate cancer development. Immunol Rev. 2008;222:145–154
- . Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol. 2002;3:991–998
- . Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood. 2001;97:192–197
- . Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci USA. 1998;95:7556–7561
- . Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J Exp Med. 2002;196:129–134
- Differential tumor surveillance by natural killer (NK) and NKT cells. J Exp Med. 2000;191:661–668
- IL-23 promotes tumour incidence and growth. Nature. 2006;442:461–465
- . Effect of interleukin 12 on tumor induction by 3-methylcholanthrene. Proc Natl Acad Sci USA. 1996;93:11798–11801
- Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. J Immunol. 1994;153:1697–1706
- . Interferons, immunity and cancer immunoediting. Nat Rev Immunol. 2006;6:836–848
- Gamma delta T cells provide an early source of interferon gamma in tumor immunity. J Exp Med. 2003;198:433–442
- . Cutting edge: spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice. J Immunol. 2000;165:6024–6028
- . Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma. J Immunol. 2000;165:6015–6019
- . Cutting edge: differentiation of antitumor CTL in vivo requires host expression of Stat1. J Immunol. 1999;163:4109–4113
- . IFN-dependent down-regulation of the NKG2D ligand H60 on tumors. J Immunol. 2006;176:905–913
- . Tumor-specific Tc1, but not Tc2, cells deliver protective antitumor immunity. J Immunol. 2001;167:6497–6502
- . Therapeutic effects of tumor-reactive type 1 and type 2 CD8+ T cell subpopulations in established pulmonary metastases. J Immunol. 1999;162:6671–6680
- . Tc1 and Tc2 effector cell therapy elicit long-term tumor immunity by contrasting mechanisms that result in complementary endogenous type 1 antitumor responses. J Immunol. 2004;172:1380–1390
- . The duplicitous effects of interleukin 4 on tumour immunity: how can the same cytokine improve or impair control of tumour growth?. Tissue Antigens. 2007;69:293–298
- . Immunotherapy of cytotoxic T cell-resistant tumors by T helper 2 cells: an eotaxin and STAT6-dependent process. J Exp Med. 2003;197:387–393
- . IL-4-transfected tumor cell vaccines activate tumor-infiltrating dendritic cells and promote type-1 immunity. J Immunol. 2005;174:7194–7201
- . A pathogenic role of Th2 cells and their cytokine products on the pulmonary metastasis of murine B16 melanoma. J Immunol. 1998;160:5869–5873
- . IL-13 effector functions. Annu Rev Immunol. 2003;21:425–456
- Experimental gene therapy of cancer using tumor cells engineered to secrete interleukin-13. Eur J Immunol. 1995;25:2340–2348
- NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol. 2000;1:515–520
- Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence. J Exp Med. 2003;198:1741–1752
- . Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer. 2004;4:71–78
- . Role of IL-13 in regulation of anti-tumor immunity and tumor growth. Cancer Immunol Immunother. 2004;53:79–85
- . Inhibition of angiogenesis by interleukin 4. J Exp Med. 1998;188:1039–1046
- . Tumor rejection by modulation of tumor stromal fibroblasts. J Exp Med. 2003;198:1487–1493
- Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development. J Exp Med. 2007;204:1037–1047
- . The unique role of natural killer T cells in the response to microorganisms. Nat Rev Microbiol. 2007;5:405–417
- . KRN7000, a novel immunomodulator, and its antitumor activities. Oncol Res. 1995;7:529–534
- CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science. 1997;278:1626–1629
- Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Science. 1997;278:1623–1626
- . A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas. J Exp Med. 2002;196:119–127
- Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide. Blood. 2002;99:1259–1266
- The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J Exp Med. 1999;189:1121–1128
- . Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein. J Exp Med. 2003;198:267–279
- . Cutting edge: inhibition of experimental tumor metastasis by dendritic cells pulsed with alpha-galactosylceramide. J Immunol. 1999;163:2387–2391
- . Immunization with alpha-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis. Eur J Immunol. 1999;29:2014–2025
- . Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs. Nat Immunol. 2002;3:867–874
- . Clinical applications of natural killer T cell-based immunotherapy for cancer. Cancer Sci. 2008;99:638–645
- . NKT cells in tumor immunity: opposing subsets define a new immunoregulatory axis. J Immunol. 2008;180:3627–3635
- A nonclassical non-Valpha14Jalpha18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance. J Exp Med. 2005;202:1627–1633
- Cross-regulation between type I and type II NKT cells in regulating tumor immunity: a new immunoregulatory axis. J Immunol. 2007;179:5126–5136
- . Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease. J Clin Invest. 2007;117:2302–2312
- . Resistance to metastatic disease in STAT6-deficient mice requires hemopoietic and nonhemopoietic cells and is IFN-gamma dependent. J Immunol. 2002;169:5796–5804
- CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-beta. Cancer Res. 2006;66:3869–3875
- Differential antitumor immunity mediated by NKT cell subsets in vivo. J Exp Med. 2005;202:1279–1288
- . Distinct functional lineages of human V(alpha)24 natural killer T cells. J Exp Med. 2002;195:637–641
- . Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J Exp Med. 2002;195:625–636
- Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages. J Clin Invest. 2009;119:1524–1536
- . Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986;136:2348–2357
PII: S1359-6101(09)00109-9
doi: 10.1016/j.cytogfr.2009.11.002
© 2009 Elsevier Ltd. All rights reserved.
« Previous
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Cytokine & Growth Factor Reviews
Volume 21, Issue 1
, Pages 3-10
, February 2010
