-
Plasticity and cross-talk of Interleukin 6-type cytokines
17 May 2012
Christoph Garbers, Heike M. Hermanns, Fred Schaper, Gerhard Müller-Newen, Joachim Grötzinger, Stefan Rose-John, Jürgen Scheller
Abstract: Interleukin (IL)-6-type cytokines are critically involved in health and disease. The duration and strength of IL-6-type cytokine-mediated signaling is tightly regulated to avoid overshooting...
-
SOCS3 in immune regulation of inflammatory bowel disease and inflammatory bowel disease-related cancer
16 May 2012
Yi Li, Colin de Haar, Maikel P. Peppelenbosch, C. Janneke van der Woude
Abstract: Inflammatory bowel disease (IBD) has unclear pathogenesis and it is related to the increasing risk of developing colorectal cancer (CRC). Recent studies have uncovered the molecular mechanis...
-
Insensitivity to the growth inhibitory effects of activin A: An acquired capability in prostate cancer progression
14 May 2012
Edward Ottley, Elspeth Gold
Abstract: Prostate cancer (PCa), the most common non-skin cancer in men, is a worldwide health concern. Treatment options for aggressive PCa are limited to androgen deprivation therapies (ADT), which ...
-
Interleukin-6, its role in fibrosing conditions
07 May 2012
Steven O’Reilly, Marzena Ciechomska, Rachel Cant, Thomas Hügle, Jacob M. van Laar
Abstract: Interleukin-6 is a classic pro-inflammatory cytokine needed to mount an effective immune response. It is secreted by a wide array of cell types, however, its target cells are more restricted...
-
Emerging roles for TNIP1 in regulating post-receptor signaling
30 April 2012
Vincent P. Ramirez, Igor Gurevich, Brian J. Aneskievich
Abstract: A vast number of cellular processes and signaling pathways are regulated by various receptors, ranging from transmembrane to nuclear receptors. These receptor-mediated processes are modulate...
View More Articles in Press...
